Easy Cheeseburger Bake Casserole with Bisquick

This cheeseburger bake casserole recipe is an easy dinner idea. Make this main dish with Bisquick, seasoned ground beef, and cheese to share comfort food with the family or overnight guests.

Easy Cheeseburger Bake Casserole

I love one dish meals in the fall and winter. They’re comfort food and they make dinner prep easier while juggling schedules for school and activities.

Growing up in the South, we made casseroles for everything from potlucks and covered dish dinners, to supper for overnight guests or to take to new moms.

This one uses ground beef in a way other than burgers, meatloaf, Italian, or Mexican. It’s an easy casserole that’s like a cheeseburger in a single hot dish!

How to make Cheeseburger casserole with Bisquick

This main dish is a take on the classic Impossible Cheeseburger pie recipe. You can find many variations of the original.

This one gets more flavor and creaminess from the addition of cream cheese and seasoning added to the meat. It makes the ground beef particularly flavorful!

1. Cook ground beef and onions together in a skillet until cooked through. Drain any excess oil and return meat to hot pan.
2. Break up the cream cheese into smaller pieces and add it with the ranch seasoning, to meat and combine until melted and creamy.
3. Add meat mixture to the bottom of a 13 x 9 inch baking dish.
4. Layer on the mushrooms and 1 1/2 cup of the cheese.
5. Stir together Bisquick, milk, basil, pepper, and eggs until blended. Pour into baking dish.
6. Bake 30 minutes in a preheated 400 degree oven, or until a pick inserted into the middle comes out clean.
7. Sprinkle with remaining cheese and bake about 2 more minutes until cheese is melted.

Can I make it ahead?

Yes, this dish is nice and hearty and can be prepared ahead of time and kept in the refrigerator until ready to bake.

TIP: Never put a cold dish from the refrigerator straight into a hot oven. Put the dish into the oven and then turn it on so they heat up together. Bake as directed.

Can I freeze cheeseburger casserole?

Yes, you can freeze this after you bake it. Just let it cool completely and wrap it with a double layer of plastic wrap or aluminum foil. Freeze for up to 3 months.

Tips and Substitutions

Follow these suggestions for variations.

• Use Swiss cheese instead of cheddar, or use a combination of the two.
• Substitute fresh sliced mushrooms instead of canned or jarred.
• Use ground turkey or chicken instead of beef.
• Make your own ranch seasoning mix.

More dinner casserole recipes

Here are some of my favorite hot dishes to make for dinner.

• Make-ahead sausage egg bake can be made for brunch or dinner. It also uses Bisquick in the recipe and has a South-Western twist.
• My Mexican pasta bake casserole is an all time favorite with everyone who eats it!
• This hot chicken salad is particularly good for ladies luncheons or showers. It’s loaded with flavor and texture.
• My baked spaghetti is another crowd pleaser, and I make it a little healthier with some alternate ingredients like ground turkey and whole wheat pasta.

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